Welcome to The Graham Group

Ecological and evolutionary immunology

We aim to understand how natural selection has shaped strategies for both host defense and parasite transmission. We are especially interested in discovering why hosts are so heterogeneous in immune responsiveness. Our laboratory methods will be familiar to immunologists, but our questions as well as our quantitative methods are drawn from evolutionary ecology.

We are fascinated by how immune system behavior emerges from the actions of individual cells.  And, of the myriad molecules that power the mammalian immune system, our favorites are cytokines and antibodies. Cytokines are intercellular signalling molecules that determine the type and magnitude of parasite-killing mechanisms enabled; antibodies are among the most potent and specific of those mechanisms. Thanks to excellent graduate students, we often study parasites and defense mechanisms of insect hosts, too. 

In all of these systems, we assess effects of immune responses upon both host and parasite fitness, the selection pressures that shape the type, speed and specificity of immune responses, and the selection pressures that hone strategies for parasite virulence and transmission.

For more on our research, please see our Research and Papers pages.  You can also find Andrea on databases such as  ORCID, ResearchGate, and NCBI.  For glimpses of our field sites, collaborators, dinner parties, and lanturnip (!), please see our photo galleries.

For further information on collaborative networks, please check out the websites of the EEB Disease Group, the Princeton Global Health Program, and our RCN on Infectious Disease Evolution Across Scales.  You may notice that we hosted the Ecology & Evolution of Infectious Diseases (EEID) conference at Princeton in June 2019. As the photos attest, much fun was had, despite our norovirus-like outbreak; yikes!  

Finally and unequivocally, make no mistake: Black Lives Matter. Andrea and many Graham Group members are working for equity and social justice, both locally and afar. Andrea is happy to discuss so please just ask for the latest action and news.

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