Publications

    2017

  1. E. C. Schrom & A. L. Graham. 2017. Instructed subsets or agile swarms: How T-helper cells may adaptively counter uncertainty with variability and plasticity. Curr Opin Genet Dev 47: 75-82.
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  2. C. J. E. Metcalf, A. T. Tate & A. L. Graham. In press. Demographically framing tradeoffs between sensitivity and specificity illuminates selection on immunity. Nat Ecol Evol.
    Link to article»
    Link to commentary»

  3. A. T. Tate & A. L. Graham. 2017. Dissecting the contributions of time and microbe density to variation in immune gene expression. Proc R Soc B 284: 20170727.
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  4. R. Garnier, A. Bento, C. Hansen, J. G. Pilkington, J. M. Pemberton & A. L. Graham. 2017. Physiological proteins in resource-limited herbivores experiencing a population die-off. Naturwissenschaften 104: 68.
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  5. Q. Caudron, R. Garnier, J. G. Pilkington, K. A. Watt, C. Hansen, B. T. Grenfell, T. Aboellail & A. L. Graham. 2017. Robust extraction of quantitative structural information from high-variance histological images of livers from necropsied Soay sheep. R Soc Open Sci 4: 170111.
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  6. R. Garnier, C. Cheung, K. A. Watt, J. K. Pilkington, J. M. Pemberton & A. L. Graham. 2017. Joint associations of blood plasma proteins with overwinter survival of a large mammal. Ecol Lett 20: 175-83.
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  7. A. T. Tate, P. Andolfatto, J. Demuth & A. L. Graham. 2017. The within-host dynamics of infection in trans-generationally primed flour beetles. Mol Ecol 26: 3794–807.
    Link to article»
    Link to commentary»

  8. R. K. Plowright, C. R. Parrish, H. McCallum, P. J. Hudson, A. I. Ko, A. L. Graham & J. O. Lloyd-Smith. 2017. Pathways to zoonotic spillover. Nat Rev Microbiol 15: 502-10.
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  9. K. M. Pepin, S. L. Kay, B. Golas, S. S. Shriner, A. T. Gilbert, R. S. Miller, A. L. Graham, S. Riley, P. Cross, M. D. Samuel, M. Hooten, J. Hoeting, J. O. Lloyd-Smith, C. T. Webb
    & M. G. Buhnerkempe. 2017. Inferring infection hazard in wildlife populations by linking data across individual and population scales. Ecol Lett 20: 275-92.
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  10. M. Kennedy, A. L. Graham & A. T. Tate. 2017. Relative contributions of environmental and maternal factors to trans-generational immune priming in Tribolium castaneum. Ecol Entomol 42: 100-04.

  11. 2016

  12. A. L. Graham, D. H. Nussey, J. O. Lloyd-Smith, D. Longbottom, M. Maley, J. M. Pemberton, J. G. Pilkington, K. C. Prager, L. Smith, K. A. Watt, K. Wilson, T. N. McNeilly & F. Brulisauer. 2016. Exposure to viral and bacterial pathogens among Soay sheep of the St. Kilda archipelago. Epidemiol Infect 144: 1879-88.
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  13. R. Garnier, B. T. Grenfell, A. Nisbet, J. B. Matthews & A. L. Graham. 2016. Integrating immune mechanism to model nematode worm burden: an example in sheep. Parasitology 143: 894-904.
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  14. J. K. Peterson & A. L. Graham. 2016. What is the “true” effect of Trypanosoma rangeli on its triatomine bug vector? J Vect Ecol 41: 27-33.
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  15. J. M. Leung, T. T. H. Chau, H. D. T. Nghia, N. T. Hoa, N. V. Cuong, N. N. M. Chau, N. H. M. Dinh, S. C. L. Knowles, M. Wolbers, L. T. H. Nhat, G. E. Thwaites, A. L. Graham & S. Baker. 2016. The impact of albendazole treatment on the incidence of viral- and bacterial-induced diarrhea in school children in southern Vietnam: study protocol for a randomized controlled trial. Trials 17: 279.
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  16. J. K. Peterson, A. L. Graham, R. J. Elliott, A. P. Dobson & O. Triana Chávez. 2016. Trypanosoma cruzi-Trypanosoma rangeli co-infection ameliorates negative effects of single trypanosome infections in experimentally infected Rhodnius prolixus. Parasitology 143: 1157-67.
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  17. C. J. E. Metcalf, A. L. Graham, M. Martinez-Bakker & D. Z. Childs. 2016. Opportunities and challenges of Integral Projection Models for modeling infectious diseases and their dynamics. J Anim Ecol 85: 343-55.
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  18. R. Subramanian, A. L. Graham, B. T. Grenfell & N. Arinaminpathy. 2016. Universal or specific? A modeling-based comparison of broad-spectrum influenza vaccines against conventional, strain-matched vaccines. PLoS Comp Biol 12: e1005204.
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  19. C. J. E. Metcalf, J. Farrar, F. Cutts, N. Basta, A. L. Graham, J. Lessler, N. Ferguson, D. Burke & B. T. Grenfell. 2016. Use of serological surveys to generate key insights into the changing global landscape of infectious disease. The Lancet 388: 728-30.
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  20. 2015

  21. E. Griffiths, K. J. Fairlie-Clarke, J. E. Allen, C. J. E. Metcalf & A. L. Graham. 2015. Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes. Ecol Lett 18: 1387–96. §=equal contributions of designated authors
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  22. A. T. Tate & A. L. Graham. 2015. Trans-generational priming of resistance in wild flour beetles reflects the primed phenotypes of laboratory populations and is inhibited by co-infection with a common parasite. Funct Ecol 29: 1059-69.
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  23. K. J. Fairlie-Clarke, C. Hansen, J. E. Allen & A. L. Graham. 2015. Increased exposure to Plasmodium chabaudi antigens sustains cross-reactivity and avidity of antibodies binding Nippostrongylus brasiliensis: dissecting cross-phylum cross-reactivity in a rodent model. Parasitology 142: 1703-14.
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  24. A. T. Tate & A. L. Graham. 2015. Dynamic patterns of parasitism and immunity across host development influence optimal strategies of resource allocation. Am Nat 186: 495-512.
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  25. C. Cressler, A. L. Graham & T. Day. 2015. Evolution of hosts paying manifold costs of defence. Proc R Soc B 282: 20150065.
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  26. J. K. Peterson, A. L. Graham, A. P. Dobson & O. Triana Chávez.  2015Rhodnius prolixus life history outcomes differ when infected with different Trypanosoma cruzi I strains. Am J Trop Med Hyg 93: 564-72.
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  27. A. L. Graham. 2015. Dispatch. Evolution: Parasite pressure favors fortress-like defence. Curr Biol 25: R335-37.
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  28. O. Restif & A. L. Graham, Eds. 2015. Editorial: Within-host dynamics of infection: From ecological insights to evolutionary predictions. Phil Trans R Soc 370: 20140304.
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  29. 2014

  30. A. D. Hayward, D. H. Nussey, A. J. Wilson, C. Berenos, J. G. Pilkington, K. A. Watt, J. M. Pemberton & A. L. Graham.  2014. Natural selection on individual variation in tolerance of gastrointestinal nematode infection. PLoS Biol  12: e1001917.
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  31. A. D. Hayward, R. Garnier, K. A. Watt, J. G. Pilkington, B. T. Grenfell, J. B. Matthews, J. M. Pemberton, D. H. Nussey & A. L. Graham. 2014. Heritable, heterogeneous and costly resistance of sheep against nematodes and potential feedbacks to epidemiological dynamics.  Am Nat 184: S58-76.
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  32. R. Garnier & A. L. Graham2014. Insights from parasite-specific serological tools in eco-immunology. Integr Comp Biol  54: 363-376.
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  33. D. H. Nussey, K. A. Watt, A. Clark, J. G. Pilkington, J. M. Pemberton, A. L. Graham & T. McNeilly. 2014. Multivariate immune defences and fitness in a wild mammal: Complex but ecologically important associations among different plasma antibodies, host health and survival.  Proc R Soc B 281: 20132931.
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  34. E. Y. Klein, A. L. Graham, M. Llinas & S. Levin. 2014. Cross-reactive immune responses as primary drivers of malaria chronicity. Infect Immun 82: 140-51.
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  35. C. M. Lively, J. C. de Roode, M. Duffy, A. L. Graham & B. Koskella. 2014. Interesting open questions in disease ecology and evolution. Am Nat 184: S1-8.
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  36. 2013

  37. A. L. Graham, Ed. 2013. Optimal immunity meets natural variation: the evolutionary biology of host defence.  Parasite Immunol 35: 315-17.
    Link to editorial »
    Link to special issue »

  38. M. E. Viney & A. L. Graham2013. Patterns and processes in parasite co-infection.  In: Rollinson, D. (Ed.), Academic Press, Adv Parasitol 82: 321-370.
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  39. K. J. Fairlie-Clarke, J. E. Allen, A. F. Read & A. L. Graham2013. Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudiInfect Genet Evol 20: 270-75.
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  40. E. A. Brown, J. G. Pilkington, D. H. Nussey, K. A. Watt, A. D. Hayward, R. Tucker, A. L. Graham, S. Paterson, D. Beraldi, J. M. Pemberton & J. Slate. 2013. Detecting genes for variation in parasite burden and immunological traits in a wild population: testing the candidate gene approach. Mol Ecol 22: 757-773.
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  41. C. McCaig, A. Fenton, A. L. Graham, C. Shankland & R. Norman. 2013. Using process algebra to develop predator-prey models of within-host parasite dynamics. J Theor Biol 329: 74-81.
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  42. 2012

  43. C. J. E. Metcalf, G. H. Long, N. Mideo, J. D. Forester, O. N. Bjørnstad & A. L. Graham2012. Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.  J R Soc Interface 9: 2804-13.
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  44. H. H. Yiu, A. L. Graham & R. Stengel. 2012. Dynamics of a cytokine storm. PLoS ONE 7: e45027.
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  45. S. K. J. R. Auld, A. L. Graham, P. J. Wilson & T. J. Little.  2012. Elevated haemocyte number is associated with infection and low fitness potential in wild Daphnia magna.  Funct Ecol 26: 434-40.
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  46. D. Marco, E. Scott, D. Cairns, A. L. Graham, J. E. Allen, S. Mahajan & C. Shankland. 2012. Investigating co-infection dynamics through evolution of Bio-PEPA model parameters: a combined process algebra and evolutionary computing approach. Comp Meth Sys Biol 7605: 227-246.
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  47. A. L. Graham.   2012.   Brave new immunology: a review of Ecoimmunology, edited by G. E. Demas & R. J. Nelson.   Trends Ecol Evol 27: 656.

  48. A. L. Graham.  2012.   Review of Evolutionary Parasitology by Paul Schmid-Hempel.  Q Rev Biol 87: 76.

  49. 2011

  50. A. L. Graham, D. M. Shuker, L. C. Pollitt, S. K. J. R. Auld, A. J. Wilson & T. J. Little.  2011.  Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology.  Funct Ecol 25: 5-17.
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  51. G. H. LongA. L. Graham.  2011.  Consequences of immunopathology for pathogen virulence evolution and public health: Malaria as a case study.  Evol Appl 4: 278-91.
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  52. C. J. E. Metcalf, A. L. Graham, S. Huijben, V. C. Barclay, G. H. Long, B. T. Grenfell, A. F. Read & O. N. Bjørnstad. 2011.  Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number. Science 333: 984-88.
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  53. A. Camacho, S. Ballesteros, A. L. Graham, F. Carrat, O. Ratmann & B. Cazelles.  2011.  Explaining rapid reinfections in multiple-wave influenza outbreaks: Tristan da Cunha 1971 epidemic as a case study. Proc R Soc B 278: 3635-43.
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  54. S. A. Babayan, J. E. Allen, J. E. Bradley, M. Geuking, A. L. Graham, R. K. Grencis, J. Kaufman, K. D. McCoy, S. Paterson, K. G. C. Smith, P. J. Turnbaugh, M. E. Viney, R. M. Maizels & A. B. Pedersen.  2011.   Wild immunology: Converging on the real world.  Ann NY Acad Sci 1236: 17-29.
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  55. 2010

  56. A. L. Graham, A. D. Hayward, K. A. Watt, J. G. Pilkington, J. M. Pemberton & D. H. Nussey.  2010.  Fitness correlates of heritable variation in antibody responsiveness in a wild mammal.  Science. 330: 662-665.
    Link to article»
    Link to commentary »

  57. T. J. Little, D. M. Shuker, N. Colegrave, T. Day & A. L. Graham.  2010.  The coevolution of virulence: tolerance in perspective.  PLoS Pathog 6: e1001006.
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  58. K. J. Fairlie-Clarke, T. J. Lamb, J. Langhorne, A. L. Graham & J. E. Allen.  2010.  Antibody isotype analysis of malaria-helminth co-infection: problems and solutions associated with cross-reactivity.   BMC Immunol 11:6.
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  59. 2009

  60. K. J. Fairlie-Clarke, D. M. Shuker & A. L. Graham.  2009. Why do adaptive immune responses cross-react?  Evol Appl 2: 122-31.
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  61. M. Hoeve, K. Mylonas, K. J. Fairlie-Clarke, S. Mahajan, J. E. Allen & A. L. Graham.  2009.  Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice.   BMC Immunol 10:60.
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  62. L. Raberg, A. L. Graham & A. F. Read.  2009.  Decomposing health: Tolerance and resistance to parasites in animals.   Phil Trans R Soc B 364:37-49.
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  63. M. D. Taylor, N. van der Werf, A. Harris, A. L. Graham, O. Bain, J. E. Allen & R. M. Maizels.  2009.  Early recruitment of natural CD4+Foxp3+ regulatory T cells by infective larvae determines the outcome of filarial infection.   Eur J Immunol 39:192-206.
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  64. 2008

  65. A. L. Graham.  2008.  Ecological rules governing helminth-microparasite co-infection.  PNAS 105: 566-570.
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  66. G. H. Long, B. H. K. Chan, J. E. Allen, A. F. Read & A. L. Graham.  2008.  Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites.  BMC Evol Biol 8:128.
    Link to article»
    Link to commentary »

  67. G. H. Long, B. H. K. Chan, J. E. Allen, A. F. Read & A. L. Graham.  2008.  Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection.  Int J Parasitol 38: 1073-81.
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  68. A. Fenton, T. J. Lamb, & A. L. Graham.  2008.  Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks.  Parasitology135: 841-53.
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  69. T. J. Lamb, A. L. Graham & A. Petrie.  2008.  Commentary: t-testing the immune system.  Immunity 28: 288-92.
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  70. M. Booth, A. L. Graham & M. Viney, Eds.  2008.  Parasitic co-infections: Challenges and solutions. Parasitology 135: 749.
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  71. A. F. Read, A. L. Graham & L. Raberg.  2008.  Primer: Animal defenses against infectious agents: is damage control more important than pathogen control? PLoS Biology 6: 2638-41.
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  72. 2007

  73. A. L. Graham, I. M. Cattadori, J. Lloyd-Smith, M. Ferrari & O. Bjørnstad.  2007.  Transmission consequences of co-infection: cytokines writ large?  Trends Parasitol 23: 284-291.
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  74. T. Day, A. L. Graham & A. F. Read.  2007.  Evolution of parasite virulence when host responses cause disease.  Proc R Soc B 274: 2685-2692.
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  75. 2006

  76. G. H. Long, B. H. K. Chan, J. E. Allen, A. F. Read & A. L. Graham.  2006.  Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections.  Parasitology 133: 673-684.
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  77. 2005

  78. A. L. Graham, J. E. Allen & A. F. Read.  2005. Evolutionary causes and consequences of immunopathology.  Annu Rev Ecol Evol Syst 36: 373-97.
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  79. A. L. Graham, T. J. Lamb, A. F. Read & J. E. Allen.  2005.  Malaria-filaria co-infection in mice makes malarial disease more severe unless filarial infection achieves patency.  J Infect Dis 191: 410-21.
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  80. A. L. Graham, M. D. Taylor, L. Le Goff, T. J. Lamb, M. Magennis & J. E. Allen.  2005. Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis.  Microbes Infect 7: 612-18.
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  81. T. J. Lamb, A. L. Graham, L. Le Goff & J. E. Allen.  2005.  Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontisand Leishmania major but disease progression is altered.  Parasite Immunol 27: 317-24.
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  82. 2004 And Earlier

  83. A. L. Graham.  2003.  Effects of snail size and age upon the prevalence and intensity of avian schistosome infection: Relating lab to field studies. J Parasitol 89: 458-63.   Link »

  84. A. L. Graham.  2002.  When T-helper cells don’t help:  Immunopathology during concomitant infection.  Q Rev Biol 77: 409-33.
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  85. Le Goff, L., T. J. Lamb, A. L. Graham, Y. Harcus & J. E. Allen.  2002.  IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice.  Int J Parasitol 32: 1277-84.
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  86. A. L. Graham.  2001.  Use of an optimality model to solve the immunological puzzle of concomitant infection.  Parasitology 122: S61-4.
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  87. Begum, N., A. L. Graham, K.E. Sussman & B. Draznin. 1992. Role of cAMP in mediating effects of fasting on dephosphorylation of insulin receptor. Am J Physiol 262: E142-9.
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