Publications

    2019

  1. A. D. Hayward, R. Garnier, D. Z. Childs, B. T. Grenfell, K. A. Watt, J. G. Pilkington, J. M. Pemberton & A. L. Graham. In press. From population to individual host scale and back again: testing theories of infection and defence in the Soay sheep of St. Kilda. In: Wildlife Disease Ecology: Linking Theory to Data and Application. K. Wilson, A. Fenton & D. Tompkins, Eds. Cambridge University Press.

  2. 2018

  3. C. J. E. Metcalf & A. L. Graham. 2018. Schedule and magnitude of reproductive investment under immune tradeoffs explains sex differences in immunity. Nature Communications 9: 4391.
    Link »

  4. E. C. Cope, M. Opendak, E. A. LaMarca, S. Murthy, C. Y. Park, L. B. Olson, S. Martinez, J. M. Leung, A. L. Graham & E. Gould. In press. The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection. Hippocampus.
    Link »

  5. J. M. Leung, A. L. Graham & S. C. L. Knowles. 2018. Parasite-microbiota interactions within the vertebrate gut: synthesis through an ecological lens. Front Microbiol 9: 843.
    Link »

  6. J. M. Leung, S. A. Budischak, H. Chung The, C. Hansen, R. Bowcutt, R. Neill, M. Shellman, P. Loke & A. L. Graham. 2018. Rapid environmental effects on gut nematode susceptibility in rewilded mice. PLoS Biol 16: e2004108.
    Link »
    Link to commentary»
    Link to associated article for kids!»

  7. S. A. Budischak, A. E. Wiria, F. Hamid, L. J. Wammes, M. M. Kaisar, L. van Lieshout, E. Sartono, T. Supali, M. Yazdanbakhsh & A. L. Graham. 2018. Competing for blood: the ecology of parasite resource competition in human malaria-helminth co-infections. Ecol Lett 21: 536-45.
    Link »

  8. E. C. Schrom, J. M. Prada & A. L. Graham. 2018. Immune signaling networks: Sources of robustness and constrained evolvability during coevolution. Mol Biol Evol 35: 676–87.
    Link »

  9. S. A. Budischak, C. Hansen, Q. Caudron, R. Garnier, T. R. Kartzinel, I. Pelczer, C. Cressler, A. van Leeuwen & A. L. Graham. 2018. Feeding immunity: physiological and behavioral responses to infection and resource limitation. Front Immunol 8: 1914.
    Link »

  10. 2017

  11. A. L. Graham & A. T. Tate. 2017. Insight: Are we immune, by chance? eLife 6: e32783.
    Link »

  12. E. C. Schrom & A. L. Graham. 2017. Instructed subsets or agile swarms: How T-helper cells may adaptively counter uncertainty with variability and plasticity. Curr Opin Genet Dev 47: 75-82.
    Link »

  13. C. J. E. Metcalf, A. T. Tate & A. L. Graham. 2017. Demographically framing tradeoffs between sensitivity and specificity illuminates selection on immunity. Nat Ecol Evol 1: 1766–72.
    Link to article»
    Link to commentary»

  14. A. T. Tate & A. L. Graham. 2017. Dissecting the contributions of time and microbe density to variation in immune gene expression. Proc R Soc B 284: 20170727.
    Link »

  15. R. Garnier, A. Bento, C. Hansen, J. G. Pilkington, J. M. Pemberton & A. L. Graham. 2017. Physiological proteins in resource-limited herbivores experiencing a population die-off. Naturwissenschaften 104: 68.
    Link »

  16. Q. Caudron, R. Garnier, J. G. Pilkington, K. A. Watt, C. Hansen, B. T. Grenfell, T. Aboellail & A. L. Graham. 2017. Robust extraction of quantitative structural information from high-variance histological images of livers from necropsied Soay sheep. R Soc Open Sci 4: 170111.
    Link»

  17. R. Garnier, C. Cheung, K. A. Watt, J. K. Pilkington, J. M. Pemberton & A. L. Graham. 2017. Joint associations of blood plasma proteins with overwinter survival of a large mammal. Ecol Lett 20: 175-83.
    Link »

  18. A. T. Tate, P. Andolfatto, J. Demuth & A. L. Graham. 2017. The within-host dynamics of infection in trans-generationally primed flour beetles. Mol Ecol 26: 3794–807.
    Link to article»
    Link to commentary»

  19. R. K. Plowright, C. R. Parrish, H. McCallum, P. J. Hudson, A. I. Ko, A. L. Graham & J. O. Lloyd-Smith. 2017. Pathways to zoonotic spillover. Nat Rev Microbiol 15: 502-10.
    Link»

  20. K. M. Pepin, S. L. Kay, B. Golas, S. S. Shriner, A. T. Gilbert, R. S. Miller, A. L. Graham, S. Riley, P. Cross, M. D. Samuel, M. Hooten, J. Hoeting, J. O. Lloyd-Smith, C. T. Webb
    & M. G. Buhnerkempe. 2017. Inferring infection hazard in wildlife populations by linking data across individual and population scales. Ecol Lett 20: 275-92.
    Link »

  21. M. Kennedy, A. L. Graham & A. T. Tate. 2017. Relative contributions of environmental and maternal factors to trans-generational immune priming in Tribolium castaneum. Ecol Entomol 42: 100-04.

  22. 2016

  23. A. L. Graham, D. H. Nussey, J. O. Lloyd-Smith, D. Longbottom, M. Maley, J. M. Pemberton, J. G. Pilkington, K. C. Prager, L. Smith, K. A. Watt, K. Wilson, T. N. McNeilly & F. Brulisauer. 2016. Exposure to viral and bacterial pathogens among Soay sheep of the St. Kilda archipelago. Epidemiol Infect 144: 1879-88.
    Link »

  24. R. Garnier, B. T. Grenfell, A. Nisbet, J. B. Matthews & A. L. Graham. 2016. Integrating immune mechanism to model nematode worm burden: an example in sheep. Parasitology 143: 894-904.
    Link »

  25. J. K. Peterson & A. L. Graham. 2016. What is the “true” effect of Trypanosoma rangeli on its triatomine bug vector? J Vect Ecol 41: 27-33.
    Link »

  26. J. M. Leung, T. T. H. Chau, H. D. T. Nghia, N. T. Hoa, N. V. Cuong, N. N. M. Chau, N. H. M. Dinh, S. C. L. Knowles, M. Wolbers, L. T. H. Nhat, G. E. Thwaites, A. L. Graham & S. Baker. 2016. The impact of albendazole treatment on the incidence of viral- and bacterial-induced diarrhea in school children in southern Vietnam: study protocol for a randomized controlled trial. Trials 17: 279.
    Link »

  27. J. K. Peterson, A. L. Graham, R. J. Elliott, A. P. Dobson & O. Triana Chávez. 2016. Trypanosoma cruzi-Trypanosoma rangeli co-infection ameliorates negative effects of single trypanosome infections in experimentally infected Rhodnius prolixus. Parasitology 143: 1157-67.
    Link »

  28. C. J. E. Metcalf, A. L. Graham, M. Martinez-Bakker & D. Z. Childs. 2016. Opportunities and challenges of Integral Projection Models for modeling infectious diseases and their dynamics. J Anim Ecol 85: 343-55.
    Link »

  29. R. Subramanian, A. L. Graham, B. T. Grenfell & N. Arinaminpathy. 2016. Universal or specific? A modeling-based comparison of broad-spectrum influenza vaccines against conventional, strain-matched vaccines. PLoS Comp Biol 12: e1005204.
    Link »

  30. C. J. E. Metcalf, J. Farrar, F. Cutts, N. Basta, A. L. Graham, J. Lessler, N. Ferguson, D. Burke & B. T. Grenfell. 2016. Use of serological surveys to generate key insights into the changing global landscape of infectious disease. The Lancet 388: 728-30.
    Link »

  31. 2015

  32. E. Griffiths, K. J. Fairlie-Clarke, J. E. Allen, C. J. E. Metcalf & A. L. Graham. 2015. Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes. Ecol Lett 18: 1387–96. §=equal contributions of designated authors
    Link »

  33. A. T. Tate & A. L. Graham. 2015. Trans-generational priming of resistance in wild flour beetles reflects the primed phenotypes of laboratory populations and is inhibited by co-infection with a common parasite. Funct Ecol 29: 1059-69.
    Link »

  34. K. J. Fairlie-Clarke, C. Hansen, J. E. Allen & A. L. Graham. 2015. Increased exposure to Plasmodium chabaudi antigens sustains cross-reactivity and avidity of antibodies binding Nippostrongylus brasiliensis: dissecting cross-phylum cross-reactivity in a rodent model. Parasitology 142: 1703-14.
    Link »

  35. A. T. Tate & A. L. Graham. 2015. Dynamic patterns of parasitism and immunity across host development influence optimal strategies of resource allocation. Am Nat 186: 495-512.
    Link »

  36. C. Cressler, A. L. Graham & T. Day. 2015. Evolution of hosts paying manifold costs of defence. Proc R Soc B 282: 20150065.
    Link »

  37. J. K. Peterson, A. L. Graham, A. P. Dobson & O. Triana Chávez.  2015Rhodnius prolixus life history outcomes differ when infected with different Trypanosoma cruzi I strains. Am J Trop Med Hyg 93: 564-72.
    Link »

  38. A. L. Graham. 2015. Dispatch. Evolution: Parasite pressure favors fortress-like defence. Curr Biol 25: R335-37.
    Link »

  39. O. Restif & A. L. Graham, Eds. 2015. Editorial: Within-host dynamics of infection: From ecological insights to evolutionary predictions. Phil Trans R Soc 370: 20140304.
    Link »

  40. 2014

  41. A. D. Hayward, D. H. Nussey, A. J. Wilson, C. Berenos, J. G. Pilkington, K. A. Watt, J. M. Pemberton & A. L. Graham.  2014. Natural selection on individual variation in tolerance of gastrointestinal nematode infection. PLoS Biol  12: e1001917.
    Link »

  42. A. D. Hayward, R. Garnier, K. A. Watt, J. G. Pilkington, B. T. Grenfell, J. B. Matthews, J. M. Pemberton, D. H. Nussey & A. L. Graham. 2014. Heritable, heterogeneous and costly resistance of sheep against nematodes and potential feedbacks to epidemiological dynamics.  Am Nat 184: S58-76.
    Link »

  43. R. Garnier & A. L. Graham2014. Insights from parasite-specific serological tools in eco-immunology. Integr Comp Biol  54: 363-376.
    Link »

  44. D. H. Nussey, K. A. Watt, A. Clark, J. G. Pilkington, J. M. Pemberton, A. L. Graham & T. McNeilly. 2014. Multivariate immune defences and fitness in a wild mammal: Complex but ecologically important associations among different plasma antibodies, host health and survival.  Proc R Soc B 281: 20132931.
    Link »

  45. E. Y. Klein, A. L. Graham, M. Llinas & S. Levin. 2014. Cross-reactive immune responses as primary drivers of malaria chronicity. Infect Immun 82: 140-51.
    Link »

  46. C. M. Lively, J. C. de Roode, M. Duffy, A. L. Graham & B. Koskella. 2014. Interesting open questions in disease ecology and evolution. Am Nat 184: S1-8.
    Link »

  47. 2013

  48. A. L. Graham, Ed. 2013. Optimal immunity meets natural variation: the evolutionary biology of host defence.  Parasite Immunol 35: 315-17.
    Link to editorial »
    Link to special issue »

  49. M. E. Viney & A. L. Graham2013. Patterns and processes in parasite co-infection.  In: Rollinson, D. (Ed.), Academic Press, Adv Parasitol 82: 321-370.
    Link »

  50. K. J. Fairlie-Clarke, J. E. Allen, A. F. Read & A. L. Graham2013. Quantifying variation in the potential for antibody-mediated apparent competition among nine genotypes of the rodent malaria parasite Plasmodium chabaudiInfect Genet Evol 20: 270-75.
    Link »

  51. E. A. Brown, J. G. Pilkington, D. H. Nussey, K. A. Watt, A. D. Hayward, R. Tucker, A. L. Graham, S. Paterson, D. Beraldi, J. M. Pemberton & J. Slate. 2013. Detecting genes for variation in parasite burden and immunological traits in a wild population: testing the candidate gene approach. Mol Ecol 22: 757-773.
    Link »

  52. C. McCaig, A. Fenton, A. L. Graham, C. Shankland & R. Norman. 2013. Using process algebra to develop predator-prey models of within-host parasite dynamics. J Theor Biol 329: 74-81.
    Link »

  53. 2012

  54. C. J. E. Metcalf, G. H. Long, N. Mideo, J. D. Forester, O. N. Bjørnstad & A. L. Graham2012. Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.  J R Soc Interface 9: 2804-13.
    Link »

  55. H. H. Yiu, A. L. Graham & R. Stengel. 2012. Dynamics of a cytokine storm. PLoS ONE 7: e45027.
    Link »

  56. S. K. J. R. Auld, A. L. Graham, P. J. Wilson & T. J. Little.  2012. Elevated haemocyte number is associated with infection and low fitness potential in wild Daphnia magna.  Funct Ecol 26: 434-40.
    Link »

  57. D. Marco, E. Scott, D. Cairns, A. L. Graham, J. E. Allen, S. Mahajan & C. Shankland. 2012. Investigating co-infection dynamics through evolution of Bio-PEPA model parameters: a combined process algebra and evolutionary computing approach. Comp Meth Sys Biol 7605: 227-246.
    Link »

  58. A. L. Graham.   2012.   Brave new immunology: a review of Ecoimmunology, edited by G. E. Demas & R. J. Nelson.   Trends Ecol Evol 27: 656.

  59. A. L. Graham.  2012.   Review of Evolutionary Parasitology by Paul Schmid-Hempel.  Q Rev Biol 87: 76.

  60. 2011

  61. A. L. Graham, D. M. Shuker, L. C. Pollitt, S. K. J. R. Auld, A. J. Wilson & T. J. Little.  2011.  Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology.  Funct Ecol 25: 5-17.
    Link »

  62. G. H. LongA. L. Graham.  2011.  Consequences of immunopathology for pathogen virulence evolution and public health: Malaria as a case study.  Evol Appl 4: 278-91.
    Link »

  63. C. J. E. Metcalf, A. L. Graham, S. Huijben, V. C. Barclay, G. H. Long, B. T. Grenfell, A. F. Read & O. N. Bjørnstad. 2011.  Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number. Science 333: 984-88.
    Link »

  64. A. Camacho, S. Ballesteros, A. L. Graham, F. Carrat, O. Ratmann & B. Cazelles.  2011.  Explaining rapid reinfections in multiple-wave influenza outbreaks: Tristan da Cunha 1971 epidemic as a case study. Proc R Soc B 278: 3635-43.
    Link »

  65. S. A. Babayan, J. E. Allen, J. E. Bradley, M. Geuking, A. L. Graham, R. K. Grencis, J. Kaufman, K. D. McCoy, S. Paterson, K. G. C. Smith, P. J. Turnbaugh, M. E. Viney, R. M. Maizels & A. B. Pedersen.  2011.   Wild immunology: Converging on the real world.  Ann NY Acad Sci 1236: 17-29.
    Link »

  66. 2010

  67. A. L. Graham, A. D. Hayward, K. A. Watt, J. G. Pilkington, J. M. Pemberton & D. H. Nussey.  2010.  Fitness correlates of heritable variation in antibody responsiveness in a wild mammal.  Science. 330: 662-665.
    Link to article»
    Link to commentary »

  68. T. J. Little, D. M. Shuker, N. Colegrave, T. Day & A. L. Graham.  2010.  The coevolution of virulence: tolerance in perspective.  PLoS Pathog 6: e1001006.
    Link »

  69. K. J. Fairlie-Clarke, T. J. Lamb, J. Langhorne, A. L. Graham & J. E. Allen.  2010.  Antibody isotype analysis of malaria-helminth co-infection: problems and solutions associated with cross-reactivity.   BMC Immunol 11:6.
    Link »

  70. 2009

  71. K. J. Fairlie-Clarke, D. M. Shuker & A. L. Graham.  2009. Why do adaptive immune responses cross-react?  Evol Appl 2: 122-31.
    Link »

  72. M. Hoeve, K. Mylonas, K. J. Fairlie-Clarke, S. Mahajan, J. E. Allen & A. L. Graham.  2009.  Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice.   BMC Immunol 10:60.
    Link »

  73. L. Raberg, A. L. Graham & A. F. Read.  2009.  Decomposing health: Tolerance and resistance to parasites in animals.   Phil Trans R Soc B 364:37-49.
    Link »

  74. M. D. Taylor, N. van der Werf, A. Harris, A. L. Graham, O. Bain, J. E. Allen & R. M. Maizels.  2009.  Early recruitment of natural CD4+Foxp3+ regulatory T cells by infective larvae determines the outcome of filarial infection.   Eur J Immunol 39:192-206.
    Link »

  75. 2008

  76. A. L. Graham.  2008.  Ecological rules governing helminth-microparasite co-infection.  PNAS 105: 566-570.
    Link »

  77. G. H. Long, B. H. K. Chan, J. E. Allen, A. F. Read & A. L. Graham.  2008.  Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites.  BMC Evol Biol 8:128.
    Link to article»
    Link to commentary »

  78. G. H. Long, B. H. K. Chan, J. E. Allen, A. F. Read & A. L. Graham.  2008.  Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection.  Int J Parasitol 38: 1073-81.
    Link »

  79. A. Fenton, T. J. Lamb, & A. L. Graham.  2008.  Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks.  Parasitology135: 841-53.
    Link »

  80. T. J. Lamb, A. L. Graham & A. Petrie.  2008.  Commentary: t-testing the immune system.  Immunity 28: 288-92.
    Link »

  81. M. Booth, A. L. Graham & M. Viney, Eds.  2008.  Parasitic co-infections: Challenges and solutions. Parasitology 135: 749.
    Link »

  82. A. F. Read, A. L. Graham & L. Raberg.  2008.  Primer: Animal defenses against infectious agents: is damage control more important than pathogen control? PLoS Biology 6: 2638-41.
    Link »

  83. 2007

  84. A. L. Graham, I. M. Cattadori, J. Lloyd-Smith, M. Ferrari & O. Bjørnstad.  2007.  Transmission consequences of co-infection: cytokines writ large?  Trends Parasitol 23: 284-291.
    Link »

  85. T. Day, A. L. Graham & A. F. Read.  2007.  Evolution of parasite virulence when host responses cause disease.  Proc R Soc B 274: 2685-2692.
    Link »

  86. 2006

  87. G. H. Long, B. H. K. Chan, J. E. Allen, A. F. Read & A. L. Graham.  2006.  Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections.  Parasitology 133: 673-684.
    Link »

  88. 2005

  89. A. L. Graham, J. E. Allen & A. F. Read.  2005. Evolutionary causes and consequences of immunopathology.  Annu Rev Ecol Evol Syst 36: 373-97.
    Link »

  90. A. L. Graham, T. J. Lamb, A. F. Read & J. E. Allen.  2005.  Malaria-filaria co-infection in mice makes malarial disease more severe unless filarial infection achieves patency.  J Infect Dis 191: 410-21.
    Link »

  91. A. L. Graham, M. D. Taylor, L. Le Goff, T. J. Lamb, M. Magennis & J. E. Allen.  2005. Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis.  Microbes Infect 7: 612-18.
    Link »

  92. T. J. Lamb, A. L. Graham, L. Le Goff & J. E. Allen.  2005.  Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontisand Leishmania major but disease progression is altered.  Parasite Immunol 27: 317-24.
    Link »

  93. 2004 And Earlier

  94. A. L. Graham.  2003.  Effects of snail size and age upon the prevalence and intensity of avian schistosome infection: Relating lab to field studies. J Parasitol 89: 458-63.   Link »

  95. A. L. Graham.  2002.  When T-helper cells don’t help:  Immunopathology during concomitant infection.  Q Rev Biol 77: 409-33.
    Link »

  96. Le Goff, L., T. J. Lamb, A. L. Graham, Y. Harcus & J. E. Allen.  2002.  IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice.  Int J Parasitol 32: 1277-84.
    Link »

  97. A. L. Graham.  2001.  Use of an optimality model to solve the immunological puzzle of concomitant infection.  Parasitology 122: S61-4.
    Link »

  98. Begum, N., A. L. Graham, K.E. Sussman & B. Draznin. 1992. Role of cAMP in mediating effects of fasting on dephosphorylation of insulin receptor. Am J Physiol 262: E142-9.
    Link »