Jackie is applying top-notch immunoparasitological skills to important problems in the within-host ecology of parasites and commensals.
Ph.D. in Ecology & Evolutionary Biology
M.S. in Ecology & Evolutionary Biology
B.S. with high honors in Biological Sciences, Emphasis in Neurobiology, Physiology & Behavior
University of California, Davis
NSF Graduate Research Fellow, Princeton University
Graduate Researcher, Immune dynamics and epidemiology of helminth-microbe co-infection
Senior Research Technician in immunoparasitology, including helminth-induced protection against inflammatory disorders
New York University, Langone Medical Center
Staff Research Associate
University of California, San Francisco
Undergraduate Researcher, University of California, DavisElection to Golden Key International Honour Society, UC Davis
Election to Phi Kappa Phi Honor Society, UC Davis
Election to Phi Sigma Honor Society, UC Davis
J. M. Leung, M. Davenport, M. J. Wolff, K. E. Wiens, W. M. Abidi, M. A. Poles, I. Cho, T. Ullman, L. Mayer & Loke P. 2013. IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue. Mucosal Immunol doi: 10.1038/mi.2013.31.
J. M. Leung & P. Loke. 2013. A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity. Int J Parasitol43:253-7.
M. J. Broadhurst, A. Ardeshir, B. Kanwar, J. Mirpuri, U. M. Gundra, J. M. Leung, K. E. Wiens, I. Vujkovic-Cvijin, C. C. Kim, F. Yarovinsky, N. W. Lerche, J. M. McCune JM & P. Loke. 2012. Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog 8:e1003000.
M. J. Broadhurst, J. M. Leung, K. C. Lim, N. M. Girgis, U. M. Gundra, P. G. Fallon, M. P. Lanier, J. H. McKerrow, J. M. McCune & P. Loke. 2012. Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice. PLoS Pathogens 8: e1002883.
M. J. Wolff, J. M. Leung, M. Davenport, M. A. Poles, I. Cho & P. Loke. 2012. TH17, TH22 and TReg cells are enriched in the healthy human cecum. PLoS ONE 7: e41373.
M. J. Broadhurst*, J. M. Leung* (shared first author), V. Kahsyap, J. M. McCune, U. Mahadevan, J. H. McKerrow & P. Loke. 2010. IL-22+ CD4+ T cells are associated with therapeutic Trichuris trichiura infection in an ulcerative colitis patient. Science Translational Medicine 2: 60ra88.
P. Loke, S. N. Hammond, J. M. Leung, C. C. Kim, S. Batra, C. Rocha, A. Balmaseda & E. Harris. 2010. Gene expression patterns of DENV-1 infected children from Nicaragua reveal a distinct signature of increased metabolism. PLoS Neglected Tropical Diseases 4: e710.
P. Loke, D. Favre, P. W. Hunt, J. M. Leung, B. Kanwar, J. N. Martin, S. G. Deeks & J. M. McCune. 2010. Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from non-controllers. Blood 115: e20-32.